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Duchenne Muscular Dystrophy and Exercise - featured June 1, 2011

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Duchenne Muscular Dystrophy and Exercise
by: The National Center on Physical Activity and Disability

Pathology

Duchenne muscular dystrophy (DMD) is a genetically X-linked disorder of skeletal muscle, and is caused by primary problems of the dystrophin (Dys) gene. One in 3500 boys are affected with DMD, making DMD the most common of the human muscular dystrophies. Dystrophin has been localized to the muscle cell plasmalemma by electron-microscopic immunoperoxidase techniques, and appears to be a cytoskeletal protein. The main function of Dys is the maintenance of mechanical stability at the muscle cell membrane so normal stresses encountered during contraction can be withstood without membrane disruption.


Read the full text of "Duchenne Muscular Dystrophy and Exercise" on the NCPAD Website HERE

Table of Contents:
  • Pathology
  • Clinical Signs/Symptoms
  • Histological Characteristics
  • Exercise Effects, Animals
  • Exercise Effects, Humans
  • Exercise Guidelines
  • Summary of Guidelines
  • Tables
  • Note
  • References

Tags: Muscular Dystrophy PT Article Newsletter 3 June 2011