[Source:  Medical News Today]
From the smell of flowers to the taste of wine, our perception is strongly influenced by prior knowledge and expectations, a cognitive process known as top-down control.
In a University of California, San Diego School of Medicine study published July 13 in the online journal Nature Neuroscience, a research team led by Takaki Komiyama, PhD, assistant professor of neurosciences and neurobiology, reports that in mouse models, the brain significantly changed its visual cortex operation modes by implementing top-down processes during learning.
“We found that when the mouse assigns a new meaning to a previously neutral visual stimulus, top-down control becomes much more influential in activating the visual cortex,” said first author Hiroshi Makino, PhD, postdoctoral researcher in Komiyama’s lab. “Top-down inputs interact with specific neuron types in the visual cortex to modulate its operation modes.”
This cognitive process uses our thoughts and influences our senses. For example, when we see a word with missing letters, our brain is able to fill in the blank based on past experiences.
 
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