[Source: Medical News Today]
A multinational collaboration between researchers from Spain, Mexico and Argentina revealed, that mice could provide an insight into how specific receptor subtypes in the brain could be responsible in increasing a person’s risk for attention-deficit hyperactivity disorder (ADHD), and help explaining how stimulants work to treat symptoms of ADHD. The research was conducted by the Intramural Research Program (IRP) at the National Institute on Drug Abuse (NIDA), which is a part of the National Institutes of Health.
ADHD is associated with dysfunction of the dopamine D4 receptor subtype in addition to other disorders characterized by decreased impulse control, including drug abuse. One subtype variant of the dopamine D4 receptor, called D4.7, that has been poorly understood until now, was of particular interest to the researchers because of its higher occurrence in ADHD diagnosed patients.