'Dark Genome' Is Involved in Rett Syndrome
[Source: Science Daily]
Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences (lncRNA) in Rett syndrome.
These molecules act as supervisor agents responsible of ‘switch on’ or ‘switch off’ other genes in our genome that regulate the activity of neurons. The work has been published in the last issue of the journal RNA Biology.
Only 5% of our genetic material are genes that encode proteins. The remaining 95% is known as dark genome or non-coding DNA and its function is still unknown. Part of this DNA produces RNA molecules called noncoding long chain RNA (lncRNAs).
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